pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers boost rate of toremifene metabolism, lowering the steady-state focus in serum.pentobarbital will minimize the level or effect of montelukast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Mini